Article
FOXP1 haploinsufficiency: Phenotypes beyond behavior and intellectual disability?
American journal of medical genetics. Part A - 1 Dec 2017
Myers Angela, du Souich Christèle, Yang Connie L, Borovik Lior, Mwenifumbo Jill, Rupps Rosemarie, Study Causes, Lehman Anna, Boerkoel Cornelius F
Abstract excerpt
The forkhead box (FOX) transcription factors have roles in development, carcinogenesis, metabolism, and immunity. In humans FOXP1 mutations have been associated with language and speech defects, intellectual disability, autism spectrum disorder, facial dysmorphisms, and congenital anomalies of the kidney and urinary tract. In mice, Foxp1 plays critical roles in development of the spinal motor neurons,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.