Article
TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription.
Journal of cell science - 15 Oct 2011
Sato Tomonobu, Okumura Fumihiko, Kano Satoshi, Kondo Takeshi, Ariga Tadashi, Hatakeyama Shigetsugu
Abstract excerpt
Retinoic acid (RA), a metabolite of vitamin A, plays versatile roles in development, differentiation, cell cycles and regulation of apoptosis by regulating gene transcription through nuclear receptor activation. Ubiquitinylation, which is one of the post-translational modifications, appears to be involved in the transcriptional activity of intranuclear receptors including retinoic acid receptor α (RARα)....
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