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RARα2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma

21 May 2009

Abstract excerpt

Specific genetic alterations in multiple myeloma (MM) may cause more aggressive diseases. Paired gene array analysis on 51 samples showed that retinoic acid (RA) receptor alpha (RARalpha) expression significantly increased at relapse compared with diagnosis. RARalpha encodes 2 major isoforms: RARalpha1 and RARalpha2. In this study, we examined the function of RARalpha2 in MM. Reverse transcription-polymerase...

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PMID: 19458357
DOI: 10.1182/blood-2008-12-194126

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