Article

TRIM32 controls timely cell cycle exit in muscular differentiation through c-Myc down-regulation

2025-06-27

Abstract excerpt

Mutations in TRIM32 cause Limb-Girdle Muscular Dystrophy recessive 8 (LGMDR8), a neuromuscular disorder primarily affecting the proximal muscles of hips and shoulders. However, the precise pathogenic mechanism remains unclear. In this study, we used Trim32 knockout C2C12 murine myoblasts to investigate the impact of Trim32 loss on myogenesis. We found that Trim32 deficiency leads to impaired myogenic signaling...

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Literature Corpus work: b0198df2-738d-5233-ade3-8fc20e0588d6
DOI: 10.1101/2025.06.25.661523

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