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Article

Crystal structure and role of glycans and dimerization in folding of neuronal leucine-rich repeat protein AMIGO-1.

Journal of molecular biology - 11 Nov 2011

Kajander Tommi, Kuja-Panula Juha, Rauvala Heikki, Goldman Adrian

Abstract excerpt

AMIGO-1 is the parent member of a novel family of three cell surface leucine-rich repeat (LRR) proteins. Its expression is induced by the binding of HMGB1 (high-mobility group box 1 protein) to RAGE (receptor for advanced glycation end products) on neurons. Binding of HMGB1 to RAGE is known to have a direct effect on cellular growth regulation and mobility, and AMIGO-1 directly supports growth of neuronal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21983541
DOI: 10.1016/j.jmb.2011.09.032

Genes

HMGB1

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