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Article

Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants.

Experimental gerontology - 1 May 2012

Bruno Davide, Pomara Nunzio, Nierenberg Jay, Ritchie James C, Lutz Michael W, Zetterberg Henrik, Blennow Kaj

Abstract excerpt

Neurofilament light (NFL) proteins in cerebrospinal fluid (CSF) are a marker of neuronal damage, especially subcortical axonal injury and white matter disease. Subjects with Alzheimer's disease (AD) have shown elevated levels of CSF NFL as compared to controls. However, the presence of the APOE ε4 allele, an established risk factor for AD, was not found to associate with higher CSF NFL concentrations. We examined...

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Source

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Identifiers

PMID: 21983493
DOI: 10.1016/j.exger.2011.09.008
PMCID: PMC4550703

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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