Article
Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.
The Biochemical journal - 1 Sept 2004
Forsgren Margareta, Attersand Anneli, Lake Staffan, Grünler Jacob, Swiezewska Ewa, Dallner Gustav, Climent Isabel
Abstract excerpt
The COQ2 gene in Saccharomyces cerevisiae encodes a Coq2 (p-hydroxybenzoate:polyprenyl transferase), which is required in the biosynthetic pathway of CoQ (ubiquinone). This enzyme catalyses the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group. We have isolated cDNA which we believe encodes the human homologue of COQ2 from a human muscle and liver cDNA library. The clone contained an open...
Topics
- Alkyl and Aryl Transferases
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Gene Expression Regulation, Enzymologic
- Genetic Complementation Test
- Humans
- Liver
- Mitochondrial Proteins
- Molecular Sequence Data
- Muscle, Skeletal
- Mutation
- Organ Specificity