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Article

Structures of reverse transcriptase pre- and post-excision complexes shed new light on HIV-1 AZT resistance.

Viruses - 1 Jan 2011

Scott Walter A

Abstract excerpt

HIV-1 resistance to 3'-azido-2',3'-deoxythymidine (AZT, zidovudine) results from mutations in reverse transcriptase that increase the ability of the enzyme to excise AZT-monophosphate after it has been incorporated. Crystal structures of complexes of wild type and mutant reverse transcriptase with double-stranded DNA with or without the excision product, AZT adenosine dinucleoside tetraphosphate (AZTppppA), have...

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Identifiers

PMID: 21980583
DOI: 10.3390/v3010020
PMCID: PMC3185361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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