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Article

The proteasome activator PA28 functions in collaboration with Hsp90 in vivo.

Biochemical and biophysical research communications - 16 Jun 2006

Minami Michiko, Shinozaki Fumika, Suzuki Miho, Yoshimatsu Katsuhiko, Ichikawa Yoshimasa, Minami Yasufumi

Abstract excerpt

We have previously shown that the proteasome activator PA28 is essential to Hsp90-dependent protein refolding in vitro, where PA28 mediates transfer of the Hsp90-bound substrate protein to the Hsc70/Hsp40 chaperone machine for its correct refolding. This observation suggests that PA28 may also collaborate with Hsp90 in cells. To examine this possibility, here we have used double-stranded RNA interference (RNAi)...

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Identifiers

PMID: 16650828
DOI: 10.1016/j.bbrc.2006.04.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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