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Article

Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein.

PloS one - 1 Jan 2011

Jurvansuu Jaana M, Goldman Adrian

Abstract excerpt

Transmembrane protein 18 (TMEM18) has previously been connected to cell migration and obesity. However, the molecular function of the protein has not yet been described. Here we show that TMEM18 localises to the nuclear membrane and binds to DNA in a sequence-specific manner. The protein binds DNA with its positively charged C-terminus that contains also a nuclear localisation signal. Increase in the amount of...

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Source

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Identifiers

PMID: 21980424
DOI: 10.1371/journal.pone.0025317
PMCID: PMC3182218

Genes

TMEM18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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