Article
The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent.
Pediatric diabetes - 1 Sept 2012
Gozlan Yael, Tenenbaum Ariel, Shalitin Shlomit, Lebenthal Yael, Oron Tal, Cohen Ohad, Phillip Moshe, Gat-Yablonski Galia
Abstract excerpt
BACKGROUND: Maturity-onset diabetes of the young (MODY) is characterized by an autosomal dominant mode of inheritance; a primary defect in insulin secretion with non-ketotic hyperglycemia, age of onset under 25 yr; and lack of autoantibodies. Heterozygous mutations in glucokinase (GCK) are associated with mild fasting hyperglycemia and gestational diabetes mellitus while homozygous or compound heterozygous GCK...
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