Article
Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells.
Leukemia research - 1 Feb 2014
Machado-Neto João Agostinho, de Melo Campos Paula, Favaro Patricia, Lazarini Mariana, Lorand-Metze Irene, Costa Fernando Ferreira, Olalla Saad Sara Teresinha, Traina Fabiola
Abstract excerpt
Stathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 expression have been reported in leukemia and solid tumors. However, Stathmin 1 has not been studied in myelodysplastic syndrome cells. We, herein, report that significantly higher Stathmin 1...
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