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Article

Probabilistic alignments with quality scores: an application to short-read mapping toward accurate SNP/indel detection.

Bioinformatics (Oxford, England) - 15 Nov 2011

Hamada Michiaki, Wijaya Edward, Frith Martin C, Asai Kiyoshi

Abstract excerpt

MOTIVATION: Recent studies have revealed the importance of considering quality scores of reads generated by next-generation sequence (NGS) platforms in various downstream analyses. It is also known that probabilistic alignments based on marginal probabilities (e.g. aligned-column and/or gap probabilities) provide more accurate alignment than conventional maximum score-based alignment. There exists, however, no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21976422
DOI: 10.1093/bioinformatics/btr537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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