Spontaneous shuffling of domains between introns of phage T4.

Abstract excerpt

The three self-splicing introns in phage T4 (in the td, sunY and nrdB genes) (Fig. 1a) each have the conserved group I catalytic RNA core structure (Fig. 1b), out of which is looped an open reading frame. Although the core sequences are very similar (approximately 60% identity), the open reading frames seem to be unrelated. Single crossover recombination events between homologous core sequences in the closely...

Topics

• Base Sequence
• Escherichia coli
• Genes, Viral
• Genetic Variation
• Introns
• Molecular Sequence Data
• Nucleic Acid Conformation
• RNA Splicing
• RNA, Viral
• T-Phages