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Article

Light-initiated hydroxylation of lauric acid using hybrid P450 BM3 enzymes.

Chemical communications (Cambridge, England) - 21 Nov 2011

Tran Ngoc-Han, Huynh Ngoc, Bui Thuba, Nguyen Yen, Huynh Phuong, Cooper Mary E, Cheruzel Lionel E

Abstract excerpt

We have developed hybrid P450 BM3 enzymes consisting of a Ru(II)-diimine photosensitizer covalently attached to non-native single cysteine residues of P450 BM3 heme domain mutants. These enzymes are capable, upon light activation, of selectively hydroxylating lauric acid with 40 times higher total turnover numbers compared to the peroxide shunt.

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Identifiers

PMID: 21975564
DOI: 10.1039/c1cc15124j
PMCID: PMC3213755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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