Article
TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype.
Acta neuropathologica - 1 Dec 2011
Davidson Yvonne S, Raby Samantha, Foulds Penelope G, Robinson Andrew, Thompson Jennifer C, Sikkink Stephen, Yusuf Imran, Amin Hanan, DuPlessis Daniel, Troakes Claire, Al-Sarraj Safa, Sloan Carolyn, Esiri Margaret M, Prasher Vee P, Allsop David, Neary David, Pickering-Brown Stuart M, Snowden Julie S, Mann David M A
Abstract excerpt
TDP-43 immunoreactive (TDP-43-ir) pathological changes were investigated in the temporal cortex and hippocampus of 11 patients with autosomal dominant familial forms of Alzheimer's disease (FAD), 169 patients with sporadic AD [85 with early onset disease (EOAD) (i.e before 65 years of age), and 84 with late onset after this age (LOAD)], 50 individuals with Down's Syndrome (DS) and 5 patients with primary...
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