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Article

Purifying selection shaping the evolution of the Toll-like receptor 2 TIR domain in brown hares (Lepus europaeus) from Europe and the Middle East.

Molecular biology reports - 1 Apr 2020

Stefanović Milomir, Djan Mihajla, Veličković Nevena, Demirbaş Yasin, Paule Ladislav, Gedeon Csongor István, Posautz Annika, Beiglböck Christoph, Kübber-Heiss Anna, Suchentrunk Franz

Abstract excerpt

Toll-like receptors (TLRs) are transmembrane proteins of the innate immune system, composed of the ectodomain involved in pathogen recognition and the intracellular Toll/interleukin-1 receptor (TIR) domain important for downstream signal transduction. Here, we analyze the genetic variability of TIR nucleotide and amino-acid sequences of the TLR2 gene in 243 brown hares from Europe and the Middle East and tested...

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PMID: 32236892
DOI: 10.1007/s11033-020-05382-x

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