Article
The role of tumor necrosis factor-α promoter genetic variation in Takayasu arteritis susceptibility and medical treatment.
The Journal of rheumatology - 1 Dec 2011
Lv Naqiang, Dang Aimin, Zhu Xilin, Liu Ying, Liu Yiwen, Zheng Deyu, Hui Rutai, Liu Guozhang
Abstract excerpt
OBJECTIVE: Tumor necrosis factor-α (TNF-α) is a multifunctional proinflammatory cytokine that influences the pathogenesis of Takayasu arteritis (TA). There is still no evidence of the relationship between TNF-α gene promoter polymorphisms and TA. We examined whether variations in the TNF-α promoter region may lead to TA susceptibility and disease progression. METHODS: Five TNF-α gene promoter polymorphisms...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.