Article
Function of two discrete regions is required for nuclear localization of polymerase basic protein 1 of A/WSN/33 influenza virus (H1 N1).
Molecular and cellular biology - 1 Aug 1990
Nath S T, Nayak D P
Abstract excerpt
Polymerase basic protein 1 (PB1) of influenza virus (A/WSN/33), when expressed from cloned cDNA in the absence of other viral proteins, accumulates in the nucleus. We have examined the location and nature of the nuclear localization signal of PB1 by using deletion mutants and chimeric constructio...
Topics
- Amino Acid Sequence
- Animals
- Cell Nucleus
- Chickens
- Chimera
- Chromosome Deletion
- Cloning, Molecular
- DNA, Viral
- DNA-Directed RNA Polymerases
- Escherichia coli
- Genes, Viral
- Influenza A virus
- Molecular Sequence Data
- Muscles
- Mutation
- Protein Sorting Signals
- Pyruvate Kinase
- Restriction Mapping