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Article

Overexpression of Far1, a cyclin-dependent kinase inhibitor, induces a large transcriptional reprogramming in which RNA synthesis senses Far1 in a Sfp1-mediated way.

Biotechnology advances - 1 Jan 2000

Busti Stefano, Gotti Laura, Balestrieri Chiara, Querin Lorenzo, Drovandi Guido, Felici Giovanni, Mavelli Gabriella, Bertolazzi Paola, Alberghina Lilia, Vanoni Marco

Abstract excerpt

The FAR1 gene encodes an 830 residue bifunctional protein, whose major function is inhibition of cyclin-dependent kinase complexes involved in the G1/S transition. FAR1 transcription is maximal between mitosis and early G1 phase. Enhanced FAR1 transcription is necessary but not sufficient for the pheromone-induced G1 arrest, since FAR1 overexpression itself does not trigger cell cycle arrest. Besides its well...

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Identifiers

PMID: 21964263
DOI: 10.1016/j.biotechadv.2011.09.007

Genes

FAR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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