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Mechanism for gene control by a natural allosteric group I ribozyme

29 Sept 2011

Abstract excerpt

An allosteric ribozyme consisting of a metabolite-sensing riboswitch and a group I self-splicing ribozyme was recently found in the pathogenic bacterium Clostridium difficile. The riboswitch senses the bacterial second messenger c-di-GMP, thereby controlling 5'-splice site choice by the downstream ribozyme. The proximity of this allosteric ribozyme to the open reading frame (ORF) for CD3246 suggests that...

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PMID: 21960486
DOI: 10.1261/rna.2757311

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