Article
Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein.
Biochemistry - 10 Nov 1992
Fraser P E, Nguyen J T, Inouye H, Surewicz W K, Selkoe D J, Podlisny M B, Kirschner D A
Abstract excerpt
Deposition of extraneuronal fibrils that assemble from the 39-43 residue beta/A4 amyloid protein is one of the earliest histopathological features of Alzheimer's disease. We have used negative-stain electron microscopy, Fourier-transform infrared (FT-IR) spectroscopy, and fiber X-ray diffraction to examine the structure and properties of synthetic peptides corresponding to residues 1-40 of the beta/A4 protein of...
Topics
- Amino Acid Sequence
- Amyloid beta-Peptides
- Amyloidosis
- Animals
- Cerebral Hemorrhage
- Fourier Analysis
- Haplorhini
- Humans
- Hydrogen-Ion Concentration
- Microscopy, Electron
- Molecular Sequence Data