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Article

Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.

Journal of hepatology - 1 May 1990

Sacher M, Blümel P, Thaler H, Manns M

Abstract excerpt

In this report we describe the case of a 7-year-old boy, suffering from autoimmune-type chronic active hepatitis (AI-CAH) associated with vitiligo, nail dystrophy, alopecia areata and a variant of liver kidney microsomal (LKM) autoantibodies. This patient's antibodies are different from LKM-1 which are directed against cytochrome P450 db1. They react predominantly with perivenous hepatocytes in contrast to LKM-1...

Topics

Alopecia
Autoantibodies
Autoimmune Diseases
Blotting, Western
Child
Fluorescent Antibody Technique
Genetic Variation
Hepatitis, Chronic
Humans
Male
Nail Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vitiligo

Source

Identifiers

PMID: 2195110
DOI: 10.1016/0168-8278(90)90148-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2195110-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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