Article
Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus infected patients is associated with the possession of HLA B51.
International journal of immunopathology and pharmacology - 1 Jan 2000
Bogdanos D-P, Lenzi M, Okamoto M, Rigopoulou E I, Muratori P, Ma Y, Muratori L, Tsantoulas D, Mieli- Vergani G, Bianchi F B, Vergani D
Abstract excerpt
Liver Kidney Microsomal autoantibody type 1(LKM1) directed to cytochrome P4502D6 (CYP2D6) characterises autoimmune hepatitis type-2 (AIH-2), but is also found in a proportion of chronic hepatitis C virus (HCV) infected patients, CYP2D6252-271 being a major B- cell autoepitope. Molecular mimicry and immunological cross-reactivity between CYP2D6252-271, HCV polyprotein and the infected cell protein 4 (ICP4) of...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Autoantibodies
- Binding Sites, Antibody
- Cross Reactions
- Cytochrome P-450 CYP2D6
- Female
- Genotype
- HLA-B Antigens