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Article

Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk.

Journal of lipid research - 1 Dec 2011

AlSaleh Aseel, O'Dell Sandra D, Frost Gary S, Griffin Bruce A, Lovegrove Julie A, Jebb Susan A, Sanders Thomas A B

Abstract excerpt

The PPARγ2 gene single nucleotide polymorphism (SNP) Pro12Ala has shown variable association with metabolic syndrome traits in healthy subjects. The RISCK Study investigated the effect of interaction between genotype and the ratio of polyunsaturated:saturated (P:S) fatty acid intake on plasma lip...

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Source

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Identifiers

PMID: 21949049
DOI: 10.1194/jlr.P019281
PMCID: PMC3220296

Genes

PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21949049-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk.PMID 21949049Read ↗

PPARγ2 gene Pro12Ala and PPARα gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid concentrations.Semantic proximity Read ↗

Evidence for gene-nutrient interaction at the PPARgamma locus.Semantic proximity Read ↗

Interaction between Pro12Ala polymorphism of PPARγ2 and diet on adiposity phenotypes.Semantic proximity Read ↗

Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trialSemantic proximity Read ↗

Effect of interaction between PPARG, PPARA and ADIPOQ gene variants and dietary fatty acids on plasma lipid profile and adiponectin concentration in a large intervention study.Semantic proximity Read ↗

Interactions of the PPARγ2 polymorphism with fat intake affecting energy metabolism and nutritional outcomes in obese women.Semantic proximity Read ↗

The peroxisome proliferator-activated receptor alpha Leu162Val polymorphism influences the metabolic response to a dietary intervention altering fatty acid proportions in healthy men.Semantic proximity Read ↗

Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ.Semantic proximity Read ↗

Apolipoprotein E gene polymorphism modifies fasting total cholesterol concentrations in response to replacement of dietary saturated with monounsaturated fatty acids in adults at moderate cardiovascular disease risk.Semantic proximity Read ↗

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.Semantic proximity Read ↗

Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study.Semantic proximity Read ↗

Ala12 variant of the peroxisome proliferator-activated receptor-gamma gene (PPARG) is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction.Semantic proximity Read ↗

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