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Article

Evidence for gene-nutrient interaction at the PPARgamma locus.

Diabetes - 1 Mar 2001

Luan J, Browne P O, Harding A H, Halsall D J, O'Rahilly S, Chatterjee V K, Wareham N J

Abstract excerpt

The importance of the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) in regulating insulin resistance and blood pressure has been demonstrated in families with loss of function mutations. Gain of function mutations has been associated with severe obesity. However, p...

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Identifiers

PMID: 11246892
DOI: 10.2337/diabetes.50.3.686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11246892-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Evidence for gene-nutrient interaction at the PPARgamma locus.PMID 11246892Read ↗

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The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.Semantic proximity Read ↗

Interaction between Pro12Ala polymorphism of PPARγ2 and diet on adiposity phenotypes.Semantic proximity Read ↗

Pro12Ala polymorphism of the PPARgamma2 locus modulates the relationship between energy intake and body weight in type 2 diabetic patients.Semantic proximity Read ↗

The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala PolymorphismSemantic proximity Read ↗

PPAR<i>γ</i>2<sup>Pro12Ala</sup> Polymorphism and Human HealthSemantic proximity Read ↗

Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?Semantic proximity Read ↗

Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk.Semantic proximity Read ↗

Gene-Nutrient Interaction in Type 2 Diabetes: An Appraisal of the Role of the Peroxisome Proliferator-Activated Receptor Pathway.Semantic proximity Read ↗

PPARγ2 gene Pro12Ala and PPARα gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid concentrations.Semantic proximity Read ↗

A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity.Semantic proximity Read ↗

Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities Study.Semantic proximity Read ↗

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