Stable Listeria monocytogenes live vaccine candidate strains with graded attenuation on the mouse model.

doi:10.1016/0264-410x(91)90264-7

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Article

Stable Listeria monocytogenes live vaccine candidate strains with graded attenuation on the mouse model.

Vaccine - 1 Feb 1991

Linde K, Abraham A A, Beer J

Abstract excerpt

Metabolic drift (antibiotics resistance) mutations were used to construct stable two (and three) marker vaccine candidate strains of the predominant Listeria monocytogenes serotypes 1/2a and 4b by stepwise selection. Derived from wild-type strains, spontaneous chromosomal streptomycin-resistant c...

Topics

Animals
Bacterial Vaccines
Drug Resistance, Microbial
Listeria monocytogenes
Male
Mice
Mice, Inbred ICR
Mutation
Vaccines, Attenuated
Virulence

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