Article
19F nuclear magnetic resonance study of fluoropyrimidine metabolism in strains of Candida glabrata with specific defects in pyrimidine metabolism.
Antimicrobial agents and chemotherapy - 1 Oct 1990
Fasoli M O, Kerridge D, Morris P G, Torosantucci A
Abstract excerpt
Flucytosine (5-FC)-resistant strains were isolated from the haploid opportunistic pathogen Candida glabrata by UV-induced mutation and fluoropyrimidine selection. These strains were characterized biochemically, and the metabolism of fluorinated pyrimidines was studied by 19F nuclear magnetic reso...
Topics
- Candida
- Cells, Cultured
- Cytosine Deaminase
- Flucytosine
- Fluorouracil
- Magnetic Resonance Spectroscopy
- Nucleoside Deaminases
- Pentosyltransferases
- Phenotype
- RNA, Ribosomal
- Uridine
- Uridine Kinase