Article
Evaluation of the genotoxic spectrum of cisplatin for Candida albicans.
Microbios - 1 Jan 1992
Sarachek A, Henderson L, Wilkens W E
Abstract excerpt
The platinum co-ordination complex cisplatin [cis-diamminedichloroplatinum (II)] is a highly effective anticancer drug whose activity derives from its ability to form adducts crosslinking neighbouring purine bases in DNA. Under in vitro conditions, cisplatin induced cellular inactivation, forward and reverse mutations, reciprocal and nonreciprocal mitotic recombinations and phenotypic switching in the...
Topics
- Candida albicans
- Cisplatin
- Mutation
- Phenotype
- Recombination, Genetic
- Thiosulfates