Article
Maturation of EEG oscillations in children with sodium channel mutations.
Brain & development - 1 Jun 2012
Holmes Gregory L, Bender Alex C, Wu Edie X, Scott Rod C, Lenck-Santini Pierre Pascal, Morse Richard P
Abstract excerpt
Dravet syndrome (DS) is a severe epileptic encephalopathy beginning in infancy in which children have difficult to control seizures and cognitive impairment. The majority of children with DS carry mutations of the gene Scn1a, which codes for the alpha subunit of the type 1 voltage-gated sodium channel and is important for the function of interneurons. Interneurons have a critical role in the generation of brain...
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