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Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression

1 Nov 2011

Abstract excerpt

Several studies linking alterations in differential placental methylation with pregnancy disorders have implicated (de)regulation of the placental epigenome with fetal programming and later-in-life disease. We have previously demonstrated that maternal tobacco use is associated with alterations in promoter methylation of placental CYP1A1 and that these changes are correlated with CYP1A1 gene expression and fetal...

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PMID: 21937876
DOI: 10.4161/epi.6.11.17819

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