Article
Increased sensitivity of Candida albicans cells accumulating 14 alpha-methylated sterols to active oxygen: possible relevance to in vivo efficacies of azole antifungal agents.
Antimicrobial agents and chemotherapy - 1 Aug 1992
Shimokawa O, Nakayama H
Abstract excerpt
The sensitivity of Candida albicans cells to killing by hydrogen peroxide was found to increase markedly when they were grown in the presence of sub-growth-inhibitory concentrations of the azole drug clotrimazole (CTZ). A superoxide anion-generating system consisting of xanthine and xanthine oxidase also killed such CTZ-treated cells more efficiently than control cells, but this seemed to be accounted for by...
Topics
- Antifungal Agents
- Azoles
- Candida albicans
- Culture Media
- Dealkylation
- Humans
- Hydrogen Peroxide
- In Vitro Techniques
- Oxygen
- Phagocytosis
- Phenotype