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Article

Powerful rare variant association testing in a copula-based joint analysis of multiple phenotypes.

Genetic epidemiology - 1 Jan 2020

Konigorski Stefan, Yilmaz Yildiz E, Janke Jürgen, Bergmann Manuela M, Boeing Heiner, Pischon Tobias

Abstract excerpt

In genetic association studies of rare variants, the low power of association tests is one of the main challenges. In this study, we propose a new single-marker association test called C-JAMP (Copula-based Joint Analysis of Multiple Phenotypes), which is based on a joint model of multiple phenotypes given genetic markers and other covariates. We evaluated its performance and compared its empirical type I error...

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PMID: 31732979
DOI: 10.1002/gepi.22265

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