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Article

Intrinsic Growth Deficiencies of Mesenchymal Stromal Cells in Myelodysplastic Syndromes

20 Sept 2011

Abstract excerpt

Myelodysplastic syndromes (MDSs) are clonal disorders of hematopoietic stem cells (HSCs) characterized by ineffective hematopoiesis. MDSs are responsible for 1 or several peripheral cytopenias. The evidence accumulated in recent years demonstrates that in addition to HSC defects, a particular role is also played by stromal microenvironment dysfunctions, which mediate the direct contact with hematopoietic...

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PMID: 21933023
DOI: 10.1089/scd.2011.0390

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