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The Murine Gammaherpesvirus 68 v-Cyclin Is a Critical Regulator of Reactivation from Latency

15 Aug 2000

Abstract excerpt

Gamma-2 herpesviruses encode a homolog of mammalian D-type cyclins. The v-cyclin encoded by murine gammaherpesvirus 68 (gammaHV68) induces cell cycle progression and is an oncogene (L. F. van Dyk, J. L. Hess, J. D. Katz, M. Jacoby, S. H. Speck, and H. W. Virgin IV, J. Virol. 73:5110-5122, 1999). However, the role of the pro-proliferative v-cyclins in gamma-2 herpesvirus pathogenesis is not known. Here we report...

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Identifiers

PMID: 10906198
DOI: 10.1128/jvi.74.16.7451-7461.2000

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