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HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer

19 Sept 2011

Abstract excerpt

Prostate cancer (CaP) is the most common cancer among adult men in the Western world. Better insight into its tumor-activating pathways may facilitate the development of targeted therapies. In this study, we show that patients who develop prostate tumors with low levels of PTEN and high levels of HER2/3 have a poor prognosis. This is functionally relevant, as targeting Her2 activation to the murine prostate...

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PMID: 21930937
DOI: 10.1073/pnas.1101263108

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