Article
Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma.
PloS one - 1 Jan 2014
Guo Shang, Lopez-Marquez Hector, Fan Kenneth C, Choy Edwin, Cote Gregory, Harmon David, Nielsen G Petur, Yang Cao, Zhang Changqing, Mankin Henry, Hornicek Francis J, Borger Darrell R, Duan Zhenfeng
Abstract excerpt
While liposarcoma is the second most common soft tissue malignant tumor, the molecular pathogenesis in this malignancy is poorly understood. Our goal was therefore to expand the understanding of molecular mechanisms that drive liposarcoma and identify therapeutically-susceptible genetic alterations. We studied a cohort of high-grade liposarcomas and benign lipomas across multiple disease sites, as well as two...
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