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Article

Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product.

Antimicrobial agents and chemotherapy - 1 Dec 2011

Leyssene David, Delmas Julien, Robin Frédéric, Cougnoux Antony, Gibold Lucie, Bonnet Richard

Abstract excerpt

We determined the crystal structure of an inactive Ser70Gly mutant of CTX-M-9 in complex with the bulky penicillin piperacillin at precovalent and posthydrolytic stages in the catalytic process. The structures obtained at high resolution were compared with the corresponding structures for the small penicillin benzylpenicillin and the bulky cephalosporin cefotaxime. The findings highlight the key role of the...

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Identifiers

PMID: 21930882
DOI: 10.1128/AAC.00245-11
PMCID: PMC3232781

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Source receipt: pubmed, retrieved 7 Sept 2026.

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