Article
A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population.
BMC medicine - 20 Sept 2011
Zhang Yang, Zhang Hongxing, Zhai Yun, Wang Zhifu, Ma Fuchao, Wang Hongxue, Li Peiyao, Zhang Ying, Yu Lixia, Cui Ying, He Fuchu, Zhou Gangqiao
Abstract excerpt
BACKGROUND: Increases in human telomerase reverse transcriptase (TERT) expression and telomerase activity are frequently seen in nasopharyngeal carcinoma (NPC). Recently, a variable tandem-repeats polymorphism, MNS16A, located in the downstream region of the TERT gene, was identified and reported to have an effect on TERT expression and telomerase activity. We examined whether the functional MNS16A was related to...
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