Chromosome 9 ALS and FTD locus is probably derived from a single founder.

doi:10.1016/j.neurobiolaging.2011.08.005

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Article

Chromosome 9 ALS and FTD locus is probably derived from a single founder.

Neurobiology of aging - 1 Jan 2012

Mok Kin, Traynor Bryan J, Schymick Jennifer, Tienari Pentti J, Laaksovirta Hannu, Peuralinna Terhi, Myllykangas Liisa, Chiò Adriano, Shatunov Aleksey, Boeve Bradley F, Boxer Adam L, DeJesus-Hernandez Mariely, Mackenzie Ian R, Waite Adrian, Williams Nigel, Morris Huw R, Simón-Sánchez Javier, van Swieten John C, Heutink Peter, Restagno Gabriella, Mora Gabriele, Morrison Karen E, Shaw Pamela J, Rollinson Pamela Sara, Al-Chalabi Ammar, Rademakers Rosa, Pickering-Brown Stuart, Orrell Richard W, Nalls Michael A, Hardy John

Abstract excerpt

We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that...

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Identifiers

PMID: 21925771
DOI: 10.1016/j.neurobiolaging.2011.08.005
PMCID: PMC3312749

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Chromosome 9 ALS and FTD locus is probably derived from a single founder.PMID 21925771Read ↗

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Chromosome 9p-linked families with frontotemporal dementia associated with motor neuron disease.Semantic proximity Read ↗

Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9.Semantic proximity Read ↗

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Dutch myotonic dystrophy type 2 patients and a North-African DM2 family carry the common European founder haplotype.Semantic proximity Read ↗

The Friedreich ataxia gene is assigned to chromosome 9q13-q21 by mapping of tightly linked markers and shows linkage disequilibrium with D9S15.Semantic proximity Read ↗

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