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Article

Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8.

American journal of respiratory and critical care medicine - 15 Dec 2011

Drake Kylie M, Zygmunt Deborah, Mavrakis Lori, Harbor Phyllis, Wang Lingli, Comhair Suzy A, Erzurum Serpil C, Aldred Micheala A

Abstract excerpt

RATIONALE: Heritable pulmonary arterial hypertension (HPAH) is primarily caused by mutations of the bone morphogenetic protein (BMP) type-II receptor (BMPR2). Recent identification of mutations in the downstream mediator Smad-8 (gene, SMAD9) was surprising, because loss of Smad-8 function in canonical BMP signaling is largely compensated by Smad-1 and -5. We therefore hypothesized that noncanonical pathways may...

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Share to Bone Morphogenetic Protein Receptors, Type II
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Familial Primary Pulmonary Hypertension

Share to Hypertension, Pulmonary

Share to MicroRNAs

Share to Muscle, Smooth, Vascular

Share to Pulmonary Artery

Source

Open in PubMed Open full text

Identifiers

PMID: 21920918
DOI: 10.1164/rccm.201106-1130OC
PMCID: PMC3262031

Genes

PAH
SMAD9
BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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