Article
Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.
Journal of medical genetics - 1 Jun 1998
Kawashima T, Noguchi E, Arinami T, Yamakawa-Kobayashi K, Nakagawa H, Otsuka F, Hamaguchi H
Abstract excerpt
We examined linkage between markers at and near the IL4 gene and atopic dermatitis (AD) in 88 Japanese nuclear families. Affected sib pair analysis suggested linkage between the IL4 gene and AD (SPLINK lod=2.28). Transmission disequilibrium testing showed a significantly preferential transmission...
Topics
- Case-Control Studies
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Dermatitis, Atopic
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Interleukin-4
- Japan
- Linkage Disequilibrium
- Nuclear Family
- Odds Ratio
- Point Mutation
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Promoter Regions, Genetic