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Article

Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.

Journal of medical genetics - 1 Jun 1998

Kawashima T, Noguchi E, Arinami T, Yamakawa-Kobayashi K, Nakagawa H, Otsuka F, Hamaguchi H

Abstract excerpt

We examined linkage between markers at and near the IL4 gene and atopic dermatitis (AD) in 88 Japanese nuclear families. Affected sib pair analysis suggested linkage between the IL4 gene and AD (SPLINK lod=2.28). Transmission disequilibrium testing showed a significantly preferential transmission to AD offspring of the T allele of the -590C/T polymorphism of the IL4 gene (p=0.001). A case-control comparison...

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Identifiers

PMID: 9643293
DOI: 10.1136/jmg.35.6.502
PMCID: PMC1051346

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