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Article

Therapeutic potential of PARP inhibitors for metastatic breast cancer

1 Aug 2011

Abstract excerpt

Increasing understanding of the cellular aberrations inherent to cancer cells has allowed the development of therapies to target biological pathways, an important step towards individualization of breast cancer therapy. The clinical development of poly(ADP-ribose) polymerase (PARP) inhibitors, with their novel and selective mechanism of action, are an example of this strategy. PARP plays a key role in DNA repair...

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PMID: 21916578
DOI: 10.1586/era.11.52

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