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Advances in using PARP inhibitors to treat cancer

9 Mar 2012

Abstract excerpt

The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of cancers, and its expression has been associated with overall prognosis in cancer, especially breast cancer. A series of new therapeutic agents that are potent inhibitors of the PARP1 and PARP2 isoforms have...

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PMID: 22401667
DOI: 10.1186/1741-7015-10-25

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