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Article

PARP inhibitors in breast cancer: BRCA and beyond.

Oncology (Williston Park, N.Y.) - 1 Oct 2011

Rios Jorge, Puhalla Shannon

Abstract excerpt

DNA repair is essential for the survival of both normal and cancer cells. An elaborate set of signaling pathways detect single-strand and double-strand DNA breaks and mediate either DNA repair or apoptosis if the damage is too great to repair. Poly(adenosine diphosphate [ADP]-ribose) polymerases (PARPs) play a key role in the repair of base damage via the base excision repair pathway. Pharmacological inhibition...

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Identifiers

PMID: 22106552

Genes

BRCA1

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