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PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers

30 Mar 2019

Abstract excerpt

Poly (ADP-ribose) polymerases (PARPs) play an important role in various cellular processes, such as replication, recombination, chromatin remodeling, and DNA repair. Emphasizing PARP’s role in facilitating DNA repair, the PARP pathway has been a target for cancer researchers in developing compounds which selectively target cancer cells and increase sensitivity of cancer cells to other anticancer agents, but which...

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PMID: 30934991
DOI: 10.3390/jcm8040435

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