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Article

C-reactive protein and genetic variants and cognitive decline in old age: the PROSPER study.

PloS one - 1 Jan 2011

Mooijaart Simon P, Sattar Naveed, Trompet Stella, Polisecki Eliana, de Craen Anton J M, Schaefer Ernst J, Jahn Sabine E, van Himbergen Thomas, Welsh Paul, Ford Ian, Stott David J, Westendorp Rudi G J

Abstract excerpt

BACKGROUND: Plasma concentrations of C-reactive protein (CRP), a marker of chronic inflammation, have been associated with cognitive impairment in old age. However, it is unknown whether CRP is causally linked to cognitive decline. METHODS AND FINDINGS: Within the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) trial, with 5680 participants with a mean age of 75 years, we examined associations...

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Identifiers

PMID: 21915265
DOI: 10.1371/journal.pone.0023890
PMCID: PMC3168438

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CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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