Article
Systemic L-citrulline prevents cerebral vasospasm in haptoglobin 2-2 transgenic mice after subarachnoid hemorrhage.
Neurosurgery - 1 Mar 2012
Pradilla Gustavo, Garzon-Muvdi Tomas, Ruzevick Jacob J, Bender Matthew, Edwards Lindsay, Momin Eric N, Thompson Reid C, Tamargo Rafael J
Abstract excerpt
BACKGROUND: Nitric oxide (NO) depletion and periadventitial inflammation contribute to the pathogenesis of cerebral vasospasm. L-Citrulline increases L-arginine levels, thereby raising NO synthesis. Transgenic C57Bl6 mice with a haptoglobin (Hp) 2-2 genotype develop more severe vasospasm than wild-type (Hp 1-1) mice after subarachnoid hemorrhage (SAH). OBJECTIVE: To evaluate the toxicity of systemic L-citrulline...
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