Article
A glutamate receptor antagonist, S-4-carboxyphenylglycine (S-4-CPG), inhibits vasospasm after subarachnoid hemorrhage in haptoglobin 2-2 mice [corrected].
Neurosurgery - 1 Oct 2013
Garzon-Muvdi Tomas, Pradilla Gustavo, Ruzevick Jacob J, Bender Matthew, Edwards Lindsay, Grossman Rachel, Zhao Ming, Rudek Michelle A, Riggins Gregory, Levy Andrew, Tamargo Rafael J
Abstract excerpt
BACKGROUND: Vasospasm contributes to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (SAH). Glutamate concentrations increase after SAH and correlate with vasospasm in experimental SAH. The haptoglobin (Hp) 2-2 genotype is associated with higher risk of vasospasm after SAH. We tested the efficacy of (S)-4-carboxyphenylglycine (S-4-CPG), a metabotropic glutamate receptor inhibitor, for the...
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