Article
Methionine biosynthesis in Staphylococcus aureus is tightly controlled by a hierarchical network involving an initiator tRNA-specific T-box riboswitch.
PLoS pathogens - 1 Sept 2013
Schoenfelder Sonja M K, Marincola Gabriella, Geiger Tobias, Goerke Christiane, Wolz Christiane, Ziebuhr Wilma
Abstract excerpt
In line with the key role of methionine in protein biosynthesis initiation and many cellular processes most microorganisms have evolved mechanisms to synthesize methionine de novo. Here we demonstrate that, in the bacterial pathogen Staphylococcus aureus, a rare combination of stringent response-controlled CodY activity, T-box riboswitch and mRNA decay mechanisms regulate the synthesis and stability of methionine...
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